Antigen-specific T cell unresponsiveness in cloned helper T cells mediated via the CD2 or CD3/Ti receptor pathways.

Journal article

We have investigated the role of the CD2 protein in the negative regulation of immune function and report that similar to antigen and anti-CD3, the monoclonal anti-CD2 antibodies (T112 and T113) can induce specific unresponsiveness. Antigen and anti-CD2 tolerogenic signals both down-regulated the phenotypic expression of CD3-Ti. In contrast CD2 surface expression was up-regulated after exposure to peptide and down-regulated after anti-T112 and T113 preincubation. However, in both instances interleukin 2 receptor surface levels were increased. These phenotypic changes could only be partly explained by variations in the levels of the transcripts encoding the CD3-Ti and CD2 molecules.

Authors: Lamb, JR; Zanders, E; Sewell, W; Crumpton, M; Feldmann, M

• Publication status: Published
• Journal: European journal of immunology
• Volume: 17
• Issue: 11
• Pages: 1641-1644
• Publication date: 1987-11-01
• DOI: 10.1002/eji.1830171118
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Receptors, Immunologic; Lymphocyte Activation; T-Lymphocytes, Helper-Inducer; Humans; Clone Cells; Phenotype; Antigens, CD3; Receptors, Interleukin-2; Gene Expression Regulation; Immune Tolerance; Antigens, Differentiation, T-Lymphocyte