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The role of the septo-hippocampal cholinergic projection in T-maze rewarded alternation.

Abstract:

Administration of 192IgG-saporin, a cholinergic neurotoxin, to the medial septum destroys the cell bodies from which the septo-hippocampal cholinergic projection originates, leading to reductions in both hippocampal acetylcholinesterase (AChE) and choline acetyltransferase (ChAT). Despite reports that 192IgG-saporin-induced cholinergic loss leads to post-operative impairments in acquisition and performance of spatial memory tasks, a number of other reports have described intact spatial memory...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
Behavioural brain research
Volume:
143
Issue:
1
Pages:
41-48
Publication date:
2003-07-05
DOI:
EISSN:
1872-7549
ISSN:
0166-4328
URN:
uuid:16ae7aef-68f2-4629-a715-f106bf6e89df
Source identifiers:
21800
Local pid:
pubs:21800

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