Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

Journal article

We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

Authors: Thye, T; Vannberg, F; Wong, S; Owusu-Dabo, E; Osei, I

• Publication status: Published
• Journal: Nature genetics
• Volume: 42
• Issue: 9
• Pages: 739-741
• Publication date: 2010-09-01
• DOI: 10.1038/ng.639
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: African TB Genetics Consortium; Genome-Wide Association Study; Genetic Predisposition to Disease; Tuberculosis; Odds Ratio; Ghana; Linkage Disequilibrium; Polymorphism, Single Nucleotide; Humans; Wellcome Trust Case Control Consortium; Gambia; Genetics, Population; Genetic Loci; Case-Control Studies; Chromosomes, Human, Pair 18