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The dawn phenomenon is related to overnight growth hormone release in adolescent diabetics.

Abstract:

We have investigated the relation between nocturnal insulin requirements and nocturnal growth hormone (GH) release in 26 diabetic adolescents at various puberty stages and have examined the effect of nocturnal GH suppression on pre-breakfast insulin requirement. In all the studies, euglycaemia was maintained overnight using a computer-calculated variable-rate insulin infusion, and 15-min blood samples were collected for GH assay. During initial clamp studies, insulin infusion rates were great...

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Publication status:
Published

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Authors


Matthews, DR More by this author
Dunger, DB More by this author
Journal:
Clinical endocrinology
Volume:
33
Issue:
6
Pages:
729-737
Publication date:
1990-12-05
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
URN:
uuid:16a6dfe3-56eb-4b5e-831c-c7c29d0e7e1c
Source identifiers:
72719
Local pid:
pubs:72719

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