Journal article icon

Journal article

Mendelian randomization of blood lipids for coronary heart disease.

Abstract:

AIMS: To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian randomization. METHODS AND RESULTS: We developed weighted allele scores based on single nucleotide polymorphisms (SNPs) with established associations with HDL-C, triglycerides, and low-density lipoprotein cholesterol (LDL-C). For each trait, we constructed two scores. The first was unrestricted, including all...

Expand abstract

Actions


Access Document


Publisher copy:
10.1093/eurheartj/eht571

Authors


Holmes, MV More by this author
Asselbergs, FW More by this author
Palmer, TM More by this author
Lanktree, MB More by this author
Expand authors...
Journal:
European heart journal
Publication date:
2014-01-05
DOI:
EISSN:
1522-9645
ISSN:
0195-668X
URN:
uuid:167499a3-f283-4970-8da9-fb6e6a458f7d
Source identifiers:
447892
Local pid:
pubs:447892
Language:
English
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP