The effect of the dopamine agonist, apomorphine, on regional cerebral blood flow in normal volunteers.

Journal article

Apomorphine, a non-selective dopamine agonist, has been used as a pharmacological probe for investigating central dopaminergic neurotransmission in psychiatric illness. In this study repeated measurements of regional cerebral blood flow (rCBF) were made in normal volunteers before, and after, the administration of apomorphine (5 or 10 micrograms/kg), or placebo. The difference in rCBF, before and after drug (apomorphine versus placebo), was used to identify brain areas affected by apomorphine...

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Authors: Grasby, P; Friston, K; Bench, C; Cowen, P; Frith, C

• Publication status: Published
• Journal: Psychological medicine
• Volume: 23
• Issue: 3
• Pages: 605-612
• Publication date: 1993-08-01
• EISSN: 1469-8978
• ISSN: 0033-2917
• Language: English
• Keywords: Language Tests; Neurotransmitter Agents; Humans; Adult; Apomorphine; Cerebrovascular Circulation; Regional Blood Flow; Brain; Dopamine; Placebos; Memory; Mental Disorders; Male; Tomography, Emission-Computed