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Estrogen therapy and brain muscarinic receptor density in healthy females: a SPET study.

Abstract:

Estrogen Therapy (ET) may protect against age-related cognitive decline and neuropsychiatric disorders (e.g. Alzheimer's disease). The biological basis for this putative neuroprotective effect is not fully understood, but may include modulation of cholinergic systems. Cholinergic dysfunction has been implicated in age-related memory impairment and Alzheimer's disease. However, to date no one has investigated the effect of long-term ET on brain cholinergic muscarinic receptor aging, and relate...

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Publication status:
Published

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Publisher copy:
10.1016/j.yhbeh.2006.10.007

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
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Journal:
Hormones and behavior
Volume:
51
Issue:
2
Pages:
249-257
Publication date:
2007-02-05
DOI:
EISSN:
1095-6867
ISSN:
0018-506X
URN:
uuid:166f4869-466c-4cdc-84fb-76802c6ac011
Source identifiers:
139380
Local pid:
pubs:139380

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