- Abstract:
-
The majority of genetic risk variants for type 2 diabetes (T2D) affect insulin secretion, but the mechanisms through which they influence pancreatic islet function remain largely unknown. We functionally characterized human islets to determine secretory, biophysical, and ultrastructural features in relation to genetic risk profiles in diabetic and nondiabetic donors. Islets from donors with T2D exhibited impaired insulin secretion, which was more pronounced in lean than obese diabetic donors....
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.2337/db11-1516
-
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- Journal:
- Diabetes
- Volume:
- 61
- Issue:
- 7
- Pages:
- 1726-1733
- Publication date:
- 2012-07-05
- DOI:
- EISSN:
-
1939-327X
- ISSN:
-
0012-1797
- URN:
-
uuid:165f508c-fc37-4f05-a90c-48030a238ed6
- Source identifiers:
-
322709
- Local pid:
- pubs:322709
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes.
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