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Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes.

Abstract:

The majority of genetic risk variants for type 2 diabetes (T2D) affect insulin secretion, but the mechanisms through which they influence pancreatic islet function remain largely unknown. We functionally characterized human islets to determine secretory, biophysical, and ultrastructural features in relation to genetic risk profiles in diabetic and nondiabetic donors. Islets from donors with T2D exhibited impaired insulin secretion, which was more pronounced in lean than obese diabetic donors....

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Publication status:
Published

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Publisher copy:
10.2337/db11-1516

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Journal:
Diabetes
Volume:
61
Issue:
7
Pages:
1726-1733
Publication date:
2012-07-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:165f508c-fc37-4f05-a90c-48030a238ed6
Source identifiers:
322709
Local pid:
pubs:322709

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