Journal article

CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides.

Abstract:: 3-Aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one were synthesised and incorporated directly into triplex-forming oligonucleotides in order to utilise their extended hydrogen bonding motif for recognition of the CG base pair. All analogues demonstrated strong binding affinity and very good selectivity for CG from pH 6.2 to 7.0; a marked improvement on previous modifications.

Publication status:: Published

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APA Style

Gerrard, S. R., Edrees, M., Bouamaied, I., Fox, K., & Brown, T. (2010). CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides. Organic and Biomolecular Chemistry, 8(22), 5087–5096.

MLA Style

Gerrard, SR, et al. “CG Base Pair Recognition within DNA Triple Helices by Modified N-Methylpyrrolo-DC Nucleosides.” Organic and Biomolecular Chemistry, vol. 8, no. 22, 2010, pp. 5087–96.

Chicago Style

Gerrard, SR, M Edrees, I Bouamaied, K Fox, and T Brown. 2010. “CG Base Pair Recognition within DNA Triple Helices by Modified N-Methylpyrrolo-DC Nucleosides.” Organic and Biomolecular Chemistry 8 (22): 5087–96.
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Publisher copy:: 10.1039/c0ob00119h

Authors

+ Gerrard, SR More by this author

Role:: Author

+ Edrees, M More by this author

Role:: Author

+ Bouamaied, I More by this author

Role:: Author

+ Fox, K More by this author

Role:: Author

+ Brown, T More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

Journal:: Organic and biomolecular chemistry More from this journal
Volume:: 8
Issue:: 22
Pages:: 5087-5096
Publication date:: 2010-11-01
DOI:: 10.1039/c0ob00119h
EISSN:: 1477-0539
ISSN:: 1477-0520

Language:: English
Keywords:: Base Pairing

Ultraviolet Rays

Models, Molecular

Nucleic Acid Conformation

Nucleic Acid Denaturation

Fluorescence

Nucleosides

Hydrogen-Ion Concentration

Pyrroles

DNA
Pubs id:: pubs:399996
UUID:: uuid:16523bce-f3f3-4e79-896a-9844c1f67965
Local pid:: pubs:399996
Source identifiers:: 399996
Deposit date:: 2013-11-16
ARK identifier:: ark:/29072/ora_16523bcef3f34e79896a9844c1f67965

Terms of use

Copyright date:: 2010

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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