Fluorescence in situ hybridization analysis of circulating tumor cells in metastatic prostate cancer.
PURPOSE: To assess the feasibility of characterizing gene copy number alteration by fluorescence in situ hybridization (FISH) of circulating tumor cells (CTC) isolated using the CellSearch system in patients with progressive castration-resistant metastatic prostate cancer. EXPERIMENTAL DESIGN: We used probe combinations that included the androgen receptor (AR) and MYC genes for FISH analysis of CTC samples collected from 77 men with castration-resistant metastatic prostate cancer. RESULTS: Hi...Expand abstract
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- Clinical cancer research : an official journal of the American Association for Cancer Research
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