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C-terminal Tensin-like (CTEN) is an oncogene which alters cell motility possibly through repression of E-cadherin in colorectal cancer.

Abstract:

The Tensin gene family encodes proteins thought to modulate integrin function. C-terminal Tensin-like (CTEN) is a member of the Tensin gene family which lacks the N-terminus actin-binding domain. Cten is reported to have both oncogenic and tumour-suppressor functions. We investigated the role that Cten may play in colorectal cancer (CRC). By quantitative RT-PCR CTEN is up-regulated (i.e. > two-fold increase) in 62% of cell lines and 69% of tumours compared with normal mucosa, consistent wi...

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Publication status:
Published

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Publisher copy:
10.1002/path.2508

Authors


Albasri, A More by this author
Jackson, D More by this author
Benhasouna, A More by this author
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Journal:
The Journal of pathology
Volume:
218
Issue:
1
Pages:
57-65
Publication date:
2009-05-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:164720de-4348-4e06-a780-28399512d31b
Source identifiers:
102417
Local pid:
pubs:102417

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