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Isolation, characterization, and genetic analysis of monosomic, aneuploid mutants of Candida albicans.

Abstract:

A white, prototrophic Candida albicans strain, heterozygous for the ADE2 gene (ade2/ADE2), was treated with the antimitotic agent methyl benzimidazole carbamate, and yielded red, adenine-requiring colonies at a rate of 4 x 10(-3), an order of magnitude higher than the spontaneous rate of Ade- colony formation. These red Ade- colonies were small, growing at approximately half the rate of the parent strain, and gave rise to large red colonies spontaneously. When the chromosomes of the small red...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Molecular microbiology
Volume:
6
Issue:
2
Pages:
171-177
Publication date:
1992-01-01
DOI:
EISSN:
1365-2958
ISSN:
0950-382X
Source identifiers:
7643
Language:
English
Keywords:
Pubs id:
pubs:7643
UUID:
uuid:1641b8fa-db57-4a80-bb7f-30e89237078d
Local pid:
pubs:7643
Deposit date:
2012-12-19

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