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The mechanisms of microgliosis and pain following peripheral nerve injury.

Abstract:

Microglia are the resident macrophages in the central nervous system (CNS). Any insult to the CNS homeostasis will induce a rapid change in microglia morphology, gene expression profile and functional behaviour. These responses of microglia have been collectively known as 'microgliosis'. Interestingly, damage to the nervous system outside the CNS, such as axotomy of a peripheral nerve, can lead to microgliosis in the spinal cord. There is a variation in the degree of microgliosis depending on...

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Journal:
Experimental neurology
Volume:
234
Issue:
2
Pages:
271-282
Publication date:
2012-04-05
DOI:
EISSN:
1090-2430
ISSN:
0014-4886
URN:
uuid:161c8e87-6e93-47b8-914e-08b49038fb71
Source identifiers:
365741
Local pid:
pubs:365741

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