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Directed phenotype switching as an effective antimelanoma strategy.

Abstract:

Therapeutic resistance in melanoma and other cancers arises via irreversible genetic, and dynamic phenotypic, heterogeneity. Here, we use directed phenotype switching in melanoma to sensitize melanoma cells to lineage-specific therapy. We show that methotrexate (MTX) induces microphthalmia-associated transcription factor (MITF) expression to inhibit invasiveness and promote differentiation-associated expression of the melanocyte-specific Tyrosinase gene. Consequently, MTX sensitizes melanomas...

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Publication status:
Published

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Publisher copy:
10.1016/j.ccr.2013.05.009

Authors


Sáez-Ayala, M More by this author
Montenegro, MF More by this author
Sánchez-Del-Campo, L More by this author
Fernández-Pérez, MP More by this author
Chazarra, S More by this author
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Journal:
Cancer cell
Volume:
24
Issue:
1
Pages:
105-119
Publication date:
2013-07-05
DOI:
EISSN:
1878-3686
ISSN:
1535-6108
URN:
uuid:161ac995-067a-4915-916a-56ec423c0522
Source identifiers:
407700
Local pid:
pubs:407700

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