Journal article
Activation of glycogen phosphorylase and glycogenolysis in rat skeletal muscle by AICAR — an activator of AMP-activated protein kinase
- Abstract:
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We determined whether the cell permeable molecule AICAR, whose metabolite activates AMP-activated protein kinase (AMPK) in cells, affected glycogen metabolism in rat seleus muscle preparations in vitro. The basal and insulin-stimulated rates of radiochemical lactate formation, net lactate release and glycogen synthesis were determined. AICAR stimulated net lactate release (but not radiochemical lactate formation) only at a basal concentration of insulin. An increased rate of glycogenolysis was the likely cause of increased net lactate release as glycogen phosphorylase activity was significantly increased by AICAR. AICAR-stimulated net lactate release and phosphorylase activity were potently inhibited by insulin.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 633.1KB, Terms of use)
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- Publisher copy:
- 10.1016/0014-5793(96)00129-9
Authors
- Publisher:
- Elsevier
- Journal:
- FEBS Letters More from this journal
- Volume:
- 382
- Issue:
- 1-2
- Pages:
- 43-47
- Publication date:
- 1996-03-01
- Edition:
- Publisher's version
- DOI:
- EISSN:
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9600-1299
- ISSN:
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0014-5793
- Language:
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English
- Keywords:
- Subjects:
- UUID:
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uuid:1616cd97-6eea-411c-ac17-ad4899fed69e
- Local pid:
-
ora:8523
- Deposit date:
-
2014-06-05
- ARK identifier:
Terms of use
- Copyright holder:
- Federation of European Biochemical Societies
- Copyright date:
- 1996
- Notes:
- Copyright © 1996 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://www.elsevier.com/open-access/userlicense/1.0/
- Licence:
- Other
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