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Comparison of the effects of alpha-methyl-p-tyrosine and a tyrosine-free amino acid load on extracellular noradrenaline in the rat hippocampus in vivo.

Abstract:

Peripheral administration of an amino acid load lacking tyrosine and its precursor, phenylalanine, causes a lowering of central tyrosine levels. The aim of the present study was to examine the effects of tyrosine depletion on extracellular noradrenaline using microdialysis. Extracellular noradrenaline was measured in hippocampus of the anaesthetized rat under both baseline conditions (with reuptake inhibitor, desipramine, in the perfusion medium) and following administration of the alpha2-adr...

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Publication status:
Published

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Publisher copy:
10.1177/026988119901300408

Authors


McTavish, SF More by this author
Callado, L More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Journal of psychopharmacology (Oxford, England)
Volume:
13
Issue:
4
Pages:
379-384
Publication date:
1999-12-05
DOI:
EISSN:
1461-7285
ISSN:
0269-8811
URN:
uuid:1613a621-4c1e-47e7-ab6f-091d04483b63
Source identifiers:
185262
Local pid:
pubs:185262

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