RANKL-dependent and RANKL-independent mechanisms of macrophage-osteoclast differentiation in breast cancer.

Journal article

The cellular and humoral mechanisms accounting for tumour osteolysis in metastatic breast cancer are uncertain. Osteoclasts, the specialised multinucleated cells responsible for tumour osteolysis, are derived from monocyte/macrophage precursors. Breast cancer-derived tumour-associated macrophages (TAMs) are capable of osteoclast differentiation but the cellular and humoral mechanisms controlling this activity are uncertain. In this study, TAMs were isolated from primary breast cancers and cul...

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Authors: Lau, Y; Danks, L; Sun, S; Fox, S; Sabokbar, A

• Publication status: Published
• Journal: Breast cancer research and treatment
• Volume: 105
• Issue: 1
• Pages: 7-16
• Publication date: 2007-09-01
• DOI: 10.1007/s10549-006-9438-y
• EISSN: 1573-7217
• ISSN: 0167-6806
• Language: English
• Keywords: DNA Primers; Models, Biological; Humans; Cell Differentiation; Fibroblasts; Middle Aged; Aged; Leukocytes, Mononuclear; Female; Macrophages; Osteoclasts; Stromal Cells; Breast Neoplasms; Bone and Bones; RANK Ligand