Journal article

Effect of adrenergic antagonism on the growth hormone, prolactin and cortisol response to a synthetic opioid agonist in man.

Abstract:: The intravenous administration of 250 micrograms D-Ala2-MePhe4-Met-enkephalin-O-ol (DAMME) caused a marked increase in circulating growth hormone (GH) and prolactin (PRL), and a fall in cortisol, in 14 normal subjects. Neither the alpha 1-antagonist thymoxamine, nor the alpha 2-antagonist yohimbine, significantly altered the GH and PRL responses to DAMME, suggesting that in man the growth hormone- and prolactin-releasing effects of exogenous opioids are not mediated through adrenoceptor pathways. The fall in cortisol induced by DAMME was not affected by thymoxamine, but was significantly attenuated by yohimbine, indicating that opioids may lower circulating cortisol via an interaction with noradrenergic pathways.

Publication status:: Published

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APA Style

Bouloux, P., Grossman, A., Allolio, B., Delitala, G., & Besser, G. (1986). Effect of adrenergic antagonism on the growth hormone, prolactin and cortisol response to a synthetic opioid agonist in man. Hormone Research, 23(2), 83–90.

MLA Style

Bouloux, P, et al. “Effect of Adrenergic Antagonism on the Growth Hormone, Prolactin and Cortisol Response to a Synthetic Opioid Agonist in Man.” Hormone Research, vol. 23, no. 2, 1986, pp. 83–90.

Chicago Style

Bouloux, P, A Grossman, B Allolio, G Delitala, and G Besser. 1986. “Effect of Adrenergic Antagonism on the Growth Hormone, Prolactin and Cortisol Response to a Synthetic Opioid Agonist in Man.” Hormone Research 23 (2): 83–90.
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Publisher copy:: 10.1159/000180294

Authors

+ Bouloux, P More by this author

Role:: Author

+ Grossman, A More by this author

Institution:: University of Oxford
Division:: MSD
Department:: RDM
Sub department:: OCDEM
Role:: Author

+ Allolio, B More by this author

Role:: Author

+ Delitala, G More by this author

Role:: Author

+ Besser, G More by this author

Role:: Author

Journal:: Hormone research More from this journal
Volume:: 23
Issue:: 2
Pages:: 83-90
Publication date:: 1986-01-01
DOI:: 10.1159/000180294
EISSN:: 1423-0046
ISSN:: 0301-0163

Language:: English
Keywords:: Growth Hormone

Adult

Hydrocortisone

Prolactin

Yohimbine

Humans

Moxisylyte

D-Ala(2),MePhe(4),Met(0)-ol-enkephalin

Male
Pubs id:: pubs:138556
UUID:: uuid:160e2615-b54f-4840-a65d-8dfe3b1e9696
Local pid:: pubs:138556
Source identifiers:: 138556
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_160e2615b54f4840a65d8dfe3b1e9696

Terms of use

Copyright date:: 1986

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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