Cardiac tissue slices are becoming increasingly popular as a model system for cardiac electrophysiology and pharmacology research and development. Here, we describe in detail preparation, handling and optical mapping of trans-membrane potential and intracellular free calcium concentration transients (CaT) in ventricular tissue slices from guinea pigs and rabbits. Slices cut in the epicardium-tangential plane contained well-aligned in-slice myocardial cell strands ('fibres') in sub-epicardial ...Expand abstract
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- American Journal of Physiology: Heart and Circulatory Physiology
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Cardiac Tissue Slices: Preparation‚ Handling‚ and Successful Optical Mapping.
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