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Quantum mechanical calculations suggest that lytic polysaccharide monooxygenases use a copper-oxyl, oxygen-rebound mechanism.

Abstract:

Lytic polysaccharide monooxygenases (LPMOs) exhibit a mononuclear copper-containing active site and use dioxygen and a reducing agent to oxidatively cleave glycosidic linkages in polysaccharides. LPMOs represent a unique paradigm in carbohydrate turnover and exhibit synergy with hydrolytic enzymes in biomass depolymerization. To date, several features of copper binding to LPMOs have been elucidated, but the identity of the reactive oxygen species and the key steps in the oxidative mechanism h...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1316609111

Authors


Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
111
Issue:
1
Pages:
149-154
Publication date:
2014-01-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:16065387-d09a-44d7-a884-7ada4593d923
Source identifiers:
444271
Local pid:
pubs:444271

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