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Journal article

Reduced blood pressure after smooth muscle EFNB2 deletion and the potential association of EFNB2 mutation with human hypertension risk

Abstract:

Ephrin B2 (EFNB2) is a ligand for erythropoietin-producing hepatocellular kinases (EPH), the largest family of receptor tyrosine kinases. It has critical functions in many biological systems, but is not known to regulate blood pressure. We generated mice with a smooth muscle cell-specific deletion of EFNB2 and investigated its roles in blood pressure regulation and vascular smooth muscle cell (VSMC) contractility. Male Efnb2 knockout (KO) mice presented reduced blood pressure, while female KO...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/ejhg.2016.105

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Role:
Author
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Grant:
MOP57697, MOP69089, MOP 123389, MOP97829, MOP14496, ISO106797
Heart and Stroke Foundation of Quebec More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
European Journal of Human Genetics Journal website
Volume:
24
Pages:
1817–1825
Publication date:
2016-08-17
DOI:
EISSN:
1476-5438
ISSN:
1018-4813
URN:
uuid:160077b7-a234-4f07-8ae6-a600287fb00d
Source identifiers:
632213
Local pid:
pubs:632213

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