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Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer

Abstract:

Conceptual models of carcinogenesis typically consist of an evolutionary sequence of heritable changes in genes controlling proliferation, apoptosis, and senescence. We propose that these steps are necessary but not sufficient to produce invasive breast cancer because intraductal tumour growth is also constrained by hypoxia and acidosis that develop as cells proliferate into the lumen and away from the underlying vessels. This requires evolution of glycolytic and acid-resistant phenotypes tha...

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R. A. Gatenby More by this author
K. Smallbone More by this author
P. K. Maini More by this author
J. Averill More by this author
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Publication date:
2007
URN:
uuid:15d78f78-0d91-4a3d-8582-835b4ccdb6dc
Local pid:
oai:eprints.maths.ox.ac.uk:646

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