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Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

Abstract:

Previous attempts to identify neuroprotective targets by studying the ischemic cascade and devising ways to suppress it have failed to translate to efficacious therapies for acute ischemic stroke. We hypothesized that studying the molecular determinants of endogenous neuroprotection in two well-established paradigms, the resistance of CA3 hippocampal neurons to global ischemia and the tolerance conferred by ischemic preconditioning (IPC), would reveal new neuroprotective targets. We found tha...

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Publisher copy:
10.1038/nm.3097

Authors


Papadakis, M More by this author
Xilouri, M More by this author
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Journal:
Nature Medicine
Volume:
19
Issue:
3
Pages:
351-357
Publication date:
2013-03-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:15d65104-c66e-475f-8ca5-67e5bac2e79f
Source identifiers:
394512
Local pid:
pubs:394512
Language:
English

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