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Adult hippocampal neurogenesis is involved in anxiety-related behaviors.

Abstract:

Adult hippocampal neurogenesis is a unique example of structural plasticity, the functional role of which has been a matter of intense debate. New transgenic models have recently shown that neurogenesis participates in hippocampus-mediated learning. Here, we show that transgenic animals, in which adult hippocampal neurogenesis has been specifically impaired, exhibit a striking increase in anxiety-related behaviors. Our results indicate that neurogenesis plays an important role in the regulati...

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Publisher copy:
10.1038/mp.2009.15

Authors


Revest, JM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Funk-Reiter, C More by this author
Grosjean, N More by this author
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Journal:
Molecular psychiatry
Volume:
14
Issue:
10
Pages:
959-967
Publication date:
2009-10-05
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
URN:
uuid:15d147c6-8d6a-43f7-9104-40c036238773
Source identifiers:
329239
Local pid:
pubs:329239

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