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PNA HyBeacons for analysis of human mutations related to statin-induced myopathy.

Abstract:
Aminoalkyl and alkyne-tagged PNA HyBeacons have been synthesized, labeled with fluorescein via conventional amide bond or triazole formation (click chemistry) and used to detect single nucleotide polymorphisms (SNPs) implicated in statin-induced myopathy. The PNA HyBeacons gave much better mismatch/mutant discrimination than conventional DNA HyBeacons but smaller fluorescence changes on melting.

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Publisher copy:
10.4161/adna.18179

Authors


Kocalka, P More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Artificial DNA, PNA and XNA
Volume:
2
Issue:
3
Pages:
79-89
Publication date:
2011
DOI:
EISSN:
1949-0968
ISSN:
1949-095X
URN:
uuid:15bc5e4f-e125-4ee2-b115-062bd5db6a7c
Source identifiers:
399979
Local pid:
pubs:399979

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