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Methodology employed for the structure determination of tumour necrosis factor, a case of high non-crystallographic symmetry.

Abstract:

The structure of the protein tumour necrosis factor (TNF) was determined from crystals of space group P3(1)21 which contain six copies of the TNF monomer per crystallographic asymmetric unit [Jones, Stuart and Walker (1989). Nature (London), 338, 225-228]. The nature of these crystals (relatively high crystallographic symmetry coupled with multiple copies of the protein in the asymmetric unit) led to some peculiarly challenging problems at several points in the structure determination. In par...

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Publication status:
Published

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Publisher copy:
10.1107/s0108767391006839

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Walker, NP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Journal:
Acta crystallographica. Section A, Foundations of crystallography
Volume:
47 ( Pt 6)
Issue:
6
Pages:
753-770
Publication date:
1991-11-05
DOI:
EISSN:
1600-5724
ISSN:
0108-7673
URN:
uuid:15b9e7a0-c685-4119-9e7c-92ab6a9e963a
Source identifiers:
1493
Local pid:
pubs:1493

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