Journal article

The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa

Abstract:: Background The drug-metabolizing enzyme flavin-containing monooxygenase 2 (FMO2) is the predominant FMO isoform present in the lung of most mammals, including non-human primates. All Europeans and Asians tested have been shown to be homozygous for a nonfunctional variant, FMO2*2A, which contains a premature stop codon due to a single-nucleotide change in exon 9 (g.23238C > T). The ancestral allele, FMO2*1, encodes a functionally active protein and has been found in African-Americans (26%) ...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Veeramah, K., Thomas, M., Weale, M., Zeitlyn, D., Tarekegn, A., Bekele, E., Mendell, N., Shephard, E., Bradman, N., & Phillips, I. (2008). The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa. Pharmacogenetics and Genomics, 18(10), 877–886.

MLA Style

Veeramah, K., et al. “The Potentially Deleterious Functional Variant Flavin-Containing Monooxygenase 2*1 Is at High Frequency throughout Sub-Saharan Africa.” Pharmacogenetics and Genomics, vol. 18, no. 10, Lippincott, Williams & Wilkins, 2008, pp. 877–86.

Chicago Style

Veeramah, K, M Thomas, M Weale, D Zeitlyn, A Tarekegn, E Bekele, N Mendell, E Shephard, N Bradman, and I Phillips. 2008. “The Potentially Deleterious Functional Variant Flavin-Containing Monooxygenase 2*1 Is at High Frequency throughout Sub-Saharan Africa.” Pharmacogenetics and Genomics 18 (10): 877–86.
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Publisher copy:: 10.1097/FPC.0b013e3283097311

Authors

+ Veeramah, K More by this author

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Author

+ Thomas, M More by this author

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+ Weale, M More by this author

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+ Zeitlyn, D More by this author

Institution:

University of Oxford

Division:

SSD

Department:

SAME

Sub department:

Social & Cultural Anthropology

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+ Tarekegn, A More by this author

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Bibliographic Details

Publisher:: Lippincott, Williams & Wilkins
Journal:: Pharmacogenetics and Genomics More from this journal
Volume:: 18
Issue:: 10
Pages:: 877-886
Publication date:: 2008-10-01
DOI:: 10.1097/FPC.0b013e3283097311
ISSN:: 1744-6872

Item Description

Keywords:: sub-Saharan Africa

drug metabolism

long-range haplotype test

flavin-containing monooxygenase 2

pharmacogenetics

flavin-containing monooxygenase
Subjects:: Anthropology

Human ecology. Anthropogeography
UUID:: uuid:15b8ff34-5542-4915-8f01-baf0fb8ba26a
Local pid:: ora:4701
Deposit date:: 2010-12-23

Terms of use

Copyright holder:: Biotechnology and Biological Sciences Research Council. Melford Charitable Trust. Lippincott Williams & Wilkins, Inc
Copyright date:: 2008
Notes:: Copyright: © 2008 Lippincott Williams & Wilkins, Inc.

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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