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Journal article

Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia.

Abstract:

INTRODUCTION: Autophagy enables cells to recycle long-lived proteins or damaged organelles. Beclin 1, the mammalian orthologue of the yeast Apg6/Vps30 gene, functions as a scaffold for the formation of autophagosomes. MATERIALS AND METHOD: The immunohistochemical patterns of Beclin 1 expression and their prognostic relevance were studied in formalin-fixed tissues from 155 patients with colorectal adenocarcinoma treated with surgery alone. RESULTS: Using the weak homogeneous expression of Bec...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6605904

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences, Biomedical Research Centre
Role:
Author
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Journal:
British journal of cancer
Volume:
103
Issue:
8
Pages:
1209-1214
Publication date:
2010-10-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:15aa24fd-f839-4eba-b949-946f364cb635
Source identifiers:
119272
Local pid:
pubs:119272

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