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Differentiation impairs low pH-induced Ca2+ signaling and ERK phosphorylation in granule precursor tumour cells.

Abstract:

Extracellular acidification is a hallmark of a number of debilitating pathologies including cancer, ischemia and inflammation. We have recently shown that in human granule precursor tumour cells a fall in extracellular pH triggers increases in intracellular Ca(2+) concentration through activation of G-protein coupled proton-sensing receptors coupling to phospholipase C. This pH-dependent rise in cytosolic Ca(2+) led to activation of the extracellular signal-regulated kinase ERK, providing a m...

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Publication status:
Published

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Publisher copy:
10.1016/j.ceca.2009.01.002

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Cell calcium
Volume:
45
Issue:
4
Pages:
391-399
Publication date:
2009-04-05
DOI:
EISSN:
1532-1991
ISSN:
0143-4160
URN:
uuid:15a751ed-392d-456d-812a-a846b94300ce
Source identifiers:
106431
Local pid:
pubs:106431

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