Differentiation impairs low pH-induced Ca2+ signaling and ERK phosphorylation in granule precursor tumour cells.

Journal article

Extracellular acidification is a hallmark of a number of debilitating pathologies including cancer, ischemia and inflammation. We have recently shown that in human granule precursor tumour cells a fall in extracellular pH triggers increases in intracellular Ca(2+) concentration through activation of G-protein coupled proton-sensing receptors coupling to phospholipase C. This pH-dependent rise in cytosolic Ca(2+) led to activation of the extracellular signal-regulated kinase ERK, providing a m...

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Authors: Huang, W; Swietach, P; Vaughan-Jones, R; Glitsch, M

• Publication status: Published
• Journal: Cell calcium
• Volume: 45
• Issue: 4
• Pages: 391-399
• Publication date: 2009-04-01
• DOI: 10.1016/j.ceca.2009.01.002
• EISSN: 1532-1991
• ISSN: 0143-4160
• Language: English
• Keywords: TRPC Cation Channels; Intracellular Space; Hydrogen-Ion Concentration; Cell Proliferation; Down-Regulation; Fibroblast Growth Factor 2; Receptors, G-Protein-Coupled; Cell Differentiation; Extracellular Signal-Regulated MAP Kinases; Neoplasms; Cell Line, Tumor; Calcium Signaling; Inositol 1,4,5-Trisphosphate; Humans; Phosphorylation; Extracellular Space; Acids