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ASYMMETRIC-SYNTHESIS OF THE N-TERMINAL COMPONENT OF MICROGININ - (2S,3R)-3-AMINO-2-HYDROXYDECANOIC ACID, ITS (2R,3R)-EPIMER AND (3R)-3-AMINODECANOIC ACID

Abstract:
3-Amino-2-hydroxydecanoic acid (AHDA) is a novel amino acid which has been suggested as the N-terminal component of the recently isolated angiotensin-converting enzyme inhibitor microginin. The naturally occurring amino acid was found to possess syn relative stereochemistry and (2S,3R) absolute stereochemistry when the reported 1H and 13C nmr spectroscopic data and the CD data were compared to the spectroscopic data for synthetic (2R,3R)- and (2S,3R)-AHDA. These studies complete the stereochemical assignment of microginin. © 1994.
Publication status:
Published

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Publisher copy:
10.1016/0957-4166(94)00372-I

Authors

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author


Journal:
TETRAHEDRON-ASYMMETRY More from this journal
Volume:
6
Issue:
1
Pages:
165-176
Publication date:
1995-01-01
DOI:
EISSN:
1362-511X
ISSN:
0957-4166


Pubs id:
pubs:110856
UUID:
uuid:15a3c645-9001-4939-b0a9-872e512a68b6
Local pid:
pubs:110856
Source identifiers:
110856
Deposit date:
2012-12-19
ARK identifier:

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