Journal article icon

Journal article

MRI detection of early endothelial activation in brain inflammation.

Abstract:

MRI is an increasingly important clinical tool, but it is clear that conventional imaging fails to identify the full extent of lesion load in certain conditions, such as multiple sclerosis. The aim of this study was to determine whether a novel contrast agent (Gd-DTPA-B(sLeX)A, which contains an sLeX mimetic moiety that enables it to bind to the adhesion molecule E-selectin) can be used to identify endothelial activation in the brain. Microinjection of the proinflammatory cytokines IL-1beta o...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/mrm.10723

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Blamire, AM More by this author
Bernades-Silva, M More by this author
Laurent, S More by this author
Expand authors...
Journal:
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
Volume:
51
Issue:
2
Pages:
248-252
Publication date:
2004-02-05
DOI:
EISSN:
1522-2594
ISSN:
0740-3194
URN:
uuid:15a3624d-ffb7-4253-8b81-820eb8b3cb37
Source identifiers:
130986
Local pid:
pubs:130986

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP