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Formaldehyde--a rapid and reversible inhibitor of hydrogen production by [FeFe]-hydrogenases.

Abstract:

Dihydrogen (H(2)) production by [FeFe]-hydrogenases is strongly inhibited by formaldehyde (methanal) in a reaction that is rapid, reversible, and specific to this type of hydrogenase. This discovery, using three [FeFe]-hydrogenases that are homologous about the active site but otherwise structurally distinct, was made by protein film electrochemistry, which measures the activity (as electrical current) of enzymes immobilized on an electrode; importantly, the inhibitor can be removed after add...

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Publication status:
Published

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Publisher copy:
10.1021/ja110103p

Authors


Brandmayr, C More by this author
Stripp, ST More by this author
Cavazza, C More by this author
Fontecilla-Camps, JC More by this author
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Journal:
Journal of the American Chemical Society
Volume:
133
Issue:
5
Pages:
1282-1285
Publication date:
2011-02-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:15a0dcc5-95db-48ee-8749-cd41e82384e4
Source identifiers:
110209
Local pid:
pubs:110209

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