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When are randomised trials unnecessary? Picking signal from noise.

Abstract:

Although randomised trials are widely accepted as the ideal way of obtaining unbiased estimates of treatment effects, some treatments have dramatic effects that are highly unlikely to reflect inadequately controlled biases. We compiled a list of historical examples of such effects and identified the features of convincing inferences about treatment effects from sources other than randomised trials. A unifying principle is the size of the treatment effect (signal) relative to the expected prog...

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Publication status:
Published

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Publisher copy:
10.1136/bmj.39070.527986.68

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-CTU
Chalmers, I More by this author
Rawlins, M More by this author
McCulloch, P More by this author
Journal:
BMJ (Clinical research ed.)
Volume:
334
Issue:
7589
Pages:
349-351
Publication date:
2007-02-05
DOI:
EISSN:
1756-1833
ISSN:
0959-8138
URN:
uuid:15939a0b-c8ea-4b43-8a6c-92eb0a8fd6c5
Source identifiers:
195244
Local pid:
pubs:195244

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