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Relative sensitivities of repair-deficient mammalian cells for clonogenic survival after alpha-particle irradiation.

Abstract:

The clonogenic survival of cells of the radiation-sensitive hamster cell lines irs1, irs2, irs3 and xrs5, representing different DNA repair pathways, was compared to that of their parent lines after alpha-particle irradiation. Measurements of nuclear area were made to calculate the probability of surviving a single alpha-particle traversal, the average number of lethal lesions per track and per unit dose, along with the "intrinsic radiosensitivity" of these cells, allowing for the potential o...

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Publication status:
Published

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Publisher copy:
10.1667/rr3265

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
Radiation research
Volume:
162
Issue:
6
Pages:
667-676
Publication date:
2004-12-05
DOI:
EISSN:
1938-5404
ISSN:
0033-7587
URN:
uuid:158ff2a1-a78a-43ae-b721-32e95aa77125
Source identifiers:
131773
Local pid:
pubs:131773

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