Journal article
De-Nterm-ining GLP1R signaling bias
- Abstract:
- Biased agonism has emerged as a promising strategy for improving incretin therapeutics, yet the structural determinants of signaling bias remain incompletely understood. Building on their recent parathyroid hormone 1 receptor–β-arrestin structure, Zhao and colleagues identify extracellular loop 3 as a conformational switch controlling glucagon-like peptide-1 receptor transducer selectivity, enabling rational design of biased agonists.
- Publication status:
- In press
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 896.3KB, Terms of use)
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- Publisher copy:
- 10.1016/j.tips.2026.08.002
Authors
+ Diabetes UK
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- Funder identifier:
- https://ror.org/050rgn017
- Grant:
- AMS5971128
- 25/0006885
- 24/0006744
- 22/0006389
- 23/0006627
+ Breakthrough T1D
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- Funder identifier:
- https://ror.org/00vqxjy61
- Grant:
- 1-PNF-2025-1623-S-B
+ Medical Research Council
More from this funder
- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- APP23529
+ UK Research and Innovation
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- Funder identifier:
- https://ror.org/001aqnf71
- Grant:
- EP/X026833/1
- Publisher:
- Cell Press
- Journal:
- Trends in Pharmacological Sciences More from this journal
- Publication date:
- 2026-08-27
- Acceptance date:
- 2026-08-05
- DOI:
- EISSN:
-
1873-3735
- ISSN:
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0165-6147
- Language:
-
English
- Keywords:
- Pubs id:
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2454342
- Local pid:
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pubs:2454342
- Deposit date:
-
2026-09-02
- ARK identifier:
Terms of use
- Copyright holder:
- Broichhagen and Hodson
- Copyright date:
- 2026
- Rights statement:
- © 2026 The Author(s). Published by Elsevier Ltd. User License: Creative Commons Attribution (CC BY 4.0)
- Licence:
- CC Attribution (CC BY)
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