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Journal article

Deletion of the alpha-globin gene cluster as a cause of acquired alpha-thalassemia in myelodysplastic syndrome.

Abstract:

Rarely, myelodysplastic syndrome (MDS) is complicated by an acquired form of alpha-thalassemia (alpha-thalassemia in myelodysplastic syndrome [ATMDS]) characterized by hypochromic, microcytic, anisopoikilocytic red blood cells with hemoglobin H (HbH) inclusions. Acquired mutations in ATRX, a chromatin remodeling gene, have recently been found in 12 patients with typical features of ATMDS, though they have not been detected in MDS patients with similar red blood cell findings but little HbH. T...

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Publication status:
Published

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Publisher copy:
10.1182/blood-2003-09-3222

Authors


Steensma, DP More by this author
Viprakasit, V More by this author
Hendrick, A More by this author
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Journal:
Blood
Volume:
103
Issue:
4
Pages:
1518-1520
Publication date:
2004-02-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:1574cafd-ec83-4dc5-ae7b-e7dfcf126cbd
Source identifiers:
124880
Local pid:
pubs:124880

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