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Common variants at 12q15 and 12q24 are associated with infant head circumference.

Abstract:

To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 × 10(-10)) were robustly associated with head circumference in infancy. Althou...

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Publication status:
Published online

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Publisher copy:
10.1038/ng.2238

Authors


St Pourcain, B More by this author
Thiering, E More by this author
Mook-Kanamori, DO More by this author
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Journal:
Nature genetics
Volume:
44
Issue:
5
Pages:
532-538
Publication date:
2012-05-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:157338c6-fad3-48a5-b4eb-3ec21e7bae7d
Source identifiers:
325292
Local pid:
pubs:325292

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