Journal article
Musculoskeletal conditions may increase the risk of chronic disease: A systematic review and meta-analysis of cohort studies
- Abstract:
- Background Chronic diseases and musculoskeletal conditions have a significant global burden and frequently co-occur. Musculoskeletal conditions may contribute to the development of chronic disease; however, this has not been systematically synthesised. We aimed to investigate whether the most common musculoskeletal conditions, neck or back pain or osteoarthritis of the knee or hip contribute to the development of chronic disease. Methods We searched CINAHL, Embase, Medline, Medline in Process, PsycINFO, Scopus and Web of Science to February 08, 2018, for cohort studies reporting adjusted estimates of the association between baseline musculoskeletal conditions (neck or back pain or osteoarthritis of the knee or hip) and subsequent diagnosis of a chronic disease (cardiovascular disease, cancer, diabetes, chronic respiratory disease or obesity). Two independent reviewers performed data extraction and assessed study quality. Adjusted hazard ratios were pooled using the generic inverse variance method in random effect models, regardless of the type of musculoskeletal condition or chronic disease. PROSPERO: CRD42016039519. Results There were 13 cohort studies following 3,086,612 people. In the primary meta-analysis of adjusted estimates osteoarthritis was the exposure in eight studies and back pain in two studies and cardiovascular disease was the outcome in eight studies, cancer in one study, and diabetes in one study. Pooled adjusted estimates from these ten studies showed that people with a musculoskeletal condition have a 17% increase in the rate of developing a chronic disease compared to people without a musculoskeletal condition (hazard ratio 1.17, 95% confidence interval 1.13 to 1.22; I2 52%, total n=2,686,113). Conclusions This meta-analysis found musculoskeletal conditions may increase the risk of chronic disease. In particular, osteoarthritis appears to increase the risk of developing cardiovascular disease. Prevention and early treatment of musculoskeletal conditions and targeting associated chronic disease risk factors in people with long standing musculoskeletal conditions may play a role in preventing other chronic diseases. However, greater understanding about why musculoskeletal conditions may increase the risk of chronic disease is needed.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 978.4KB, Terms of use)
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- Publisher copy:
- 10.1186/s12916-018-1151-2
Authors
- Publisher:
- BioMed Central
- Journal:
- BMC Musculoskeletal Disorders More from this journal
- Volume:
- 167
- Issue:
- 16
- Publication date:
- 2018-09-25
- Acceptance date:
- 2018-08-15
- DOI:
- EISSN:
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1471-2474
- Keywords:
- Pubs id:
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pubs:911755
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uuid:1571dd16-856c-4dea-8cbd-9d6838bbde4a
- Local pid:
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pubs:911755
- Source identifiers:
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911755
- Deposit date:
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2018-09-03
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Terms of use
- Copyright holder:
- Williams et al
- Copyright date:
- 2018
- Notes:
- © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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- CC Attribution (CC BY)
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