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Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain.

Abstract:

During HIV/SIV infection, there is widespread programmed cell death in infected and, perhaps more importantly, uninfected cells. Much of this apoptosis is mediated by Fas-Fas ligand (FasL) interactions. Previously we demonstrated in macaques that induction of FasL expression and apoptotic cell death of both CD4(+) and CD8(+) T cells by SIV is dependent on a functional nef gene. However, the molecular mechanism whereby HIV-1 induces the expression of FasL remained poorly understood. Here we re...

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Publication status:
Published

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Publisher copy:
10.1084/jem.189.9.1489

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Journal:
Journal of experimental medicine
Volume:
189
Issue:
9
Pages:
1489-1496
Publication date:
1999-05-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Source identifiers:
31472

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