During HIV/SIV infection, there is widespread programmed cell death in infected and, perhaps more importantly, uninfected cells. Much of this apoptosis is mediated by Fas-Fas ligand (FasL) interactions. Previously we demonstrated in macaques that induction of FasL expression and apoptotic cell death of both CD4(+) and CD8(+) T cells by SIV is dependent on a functional nef gene. However, the molecular mechanism whereby HIV-1 induces the expression of FasL remained poorly understood. Here we re...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain.
If you are the owner of this record, you can report an update to it here: Report update to this record