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Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain.

Abstract:

During HIV/SIV infection, there is widespread programmed cell death in infected and, perhaps more importantly, uninfected cells. Much of this apoptosis is mediated by Fas-Fas ligand (FasL) interactions. Previously we demonstrated in macaques that induction of FasL expression and apoptotic cell death of both CD4(+) and CD8(+) T cells by SIV is dependent on a functional nef gene. However, the molecular mechanism whereby HIV-1 induces the expression of FasL remained poorly understood. Here we re...

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Publication status:
Published

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Publisher copy:
10.1084/jem.189.9.1489

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Laffert, B More by this author
Screaton, GR More by this author
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Journal:
The Journal of experimental medicine
Volume:
189
Issue:
9
Pages:
1489-1496
Publication date:
1999-05-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:156cb12b-6d2b-40b3-a776-d2294d0092ff
Source identifiers:
31472
Local pid:
pubs:31472

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