Journal article
Locked and loaded: strong TCR signaling primes anti-PD-1 therapy
- Abstract:
- With continuous T cell receptor (TCR) signaling, T cells can attenuate subsequent antigen responses through adaptive tolerance, thus averting autoimmunity, but potentially also providing refuge to developing cancers. Elliot and coworkers add to our understanding of adaptation via immune checkpoints by exploiting accelerated in vivo adaptive tolerance in the face of strong TCR signaling.
- Publication status:
- Published
- Peer review status:
- Reviewed (other)
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- Files:
-
-
(Preview, Accepted manuscript, pdf, 194.2KB, Terms of use)
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- Publisher copy:
- 10.1016/j.it.2021.10.014
Authors
- Publisher:
- Cell Press
- Journal:
- Trends in Immunology More from this journal
- Volume:
- 42
- Issue:
- 12
- Pages:
- 1066-1068
- Publication date:
- 2021-11-09
- Acceptance date:
- 2021-10-27
- DOI:
- EISSN:
-
1471-4981
- ISSN:
-
1471-4906
- Pmid:
-
34772621
- Language:
-
English
- Keywords:
- Pubs id:
-
1210550
- Local pid:
-
pubs:1210550
- Deposit date:
-
2021-11-28
- ARK identifier:
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2021
- Rights statement:
- © 2021 Elsevier Ltd. All rights reserved.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Cell Press at: https://doi.org/10.1016/j.it.2021.10.014
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