Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke.

Journal article

Multiple sclerosis (MS) and stroke pathology are characterized blood-brain barrier breakdown, leucocyte emigration, and tissue destruction. Each process is thought to involve the matrix metalloproteinases (MMP), but little is known of their expression. We undertook to investigate whether MMP expression is dependent on the nature of the CNS lesion and whether expression would coincide with the histopathology. MS or cerebral-infarct tissue was examined for the presence of gelatinase-A, gelatina...

Expand abstract

Authors: Anthony, D; Ferguson, B; Matyzak, M; Miller, K; Esiri, M

• Publication status: Published
• Journal: Neuropathology and applied neurobiology
• Volume: 23
• Issue: 5
• Pages: 406-415
• Publication date: 1997-10-01
• DOI: 10.1046/j.1365-2990.1997.00066.x
• EISSN: 1365-2990
• ISSN: 0305-1846
• Language: English
• Keywords: Matrix Metalloproteinase 3; CHO Cells; Cerebrovascular Disorders; Infarction; Chronic Disease; Immunohistochemistry; Macrophages; Matrix Metalloproteinase 2; T-Lymphocytes; Brain; Humans; Matrix Metalloproteinase 7; Acute Disease; Multiple Sclerosis; Cricetinae; Metalloendopeptidases; Animals; Matrix Metalloproteinase 9; Gelatinases; Collagenases