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Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke.

Abstract:

Multiple sclerosis (MS) and stroke pathology are characterized blood-brain barrier breakdown, leucocyte emigration, and tissue destruction. Each process is thought to involve the matrix metalloproteinases (MMP), but little is known of their expression. We undertook to investigate whether MMP expression is dependent on the nature of the CNS lesion and whether expression would coincide with the histopathology. MS or cerebral-infarct tissue was examined for the presence of gelatinase-A, gelatina...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Neuropathology and applied neurobiology
Volume:
23
Issue:
5
Pages:
406-415
Publication date:
1997-10-01
DOI:
EISSN:
1365-2990
ISSN:
0305-1846
Source identifiers:
383091

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