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Journal article

Subthalamic nucleus activity optimizes maximal effort motor responses in Parkinson's disease.

Abstract:

The neural substrates that enable individuals to achieve their fastest and strongest motor responses have long been enigmatic. Importantly, characterization of such activities may inform novel therapeutic strategies for patients with hypokinetic disorders, such as Parkinson's disease. Here, we ask whether the basal ganglia may play an important role, not only in the attainment of maximal motor responses under standard conditions but also in the setting of the performance enhancements known to...

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Publication status:
Published

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Publisher copy:
10.1093/brain/aws183

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Pogosyan, A More by this author
Foltynie, T More by this author
Limousin, P More by this author
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Journal:
Brain : a journal of neurology
Volume:
135
Issue:
Pt 9
Pages:
2766-2778
Publication date:
2012-09-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:1561b62b-3a82-4e51-99c8-328b36f841b9
Source identifiers:
350544
Local pid:
pubs:350544

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