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Extracellular regulation of type IIa receptor protein tyrosine phosphatases: mechanistic insights from structural analyses.

Abstract:

The receptor protein tyrosine phosphatases (RPTPs) exhibit a wide repertoire of cellular signalling functions. In particular, type IIa RPTP family members have recently been highlighted as hubs for extracellular interactions in neurons, regulating neuronal extension and guidance, as well as synaptic organisation. In this review, we will discuss the recent progress of structural biology investigations into the architecture of type IIa RPTP ectodomains and their interactions with extracellular ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
Journal:
Seminars in cell and developmental biology
Publication date:
2014-09-05
DOI:
EISSN:
1096-3634
ISSN:
1084-9521
URN:
uuid:1560627e-76ea-4452-98d8-5282ce22c256
Source identifiers:
485300
Local pid:
pubs:485300

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