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Journal article

Inefficient cytotoxic T lymphocyte-mediated killing of HIV-1-infected cells in vivo.

Abstract:

Understanding the role of cytotoxic T lymphocytes (CTLs) in controlling HIV-1 infection is vital for vaccine design. However, it is difficult to assess the importance of CTLs in natural infection. Different human leukocyte antigen (HLA) class I alleles are associated with different rates of progression to AIDS, indicating that CTLs play a protective role. Yet virus clearance rates following antiretroviral therapy are not impaired in individuals with advanced HIV disease, suggesting that weake...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
Journal:
PLoS biology
Volume:
4
Issue:
4
Pages:
e90
Publication date:
2006-04-05
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
URN:
uuid:15543278-b86c-4238-8e60-23c2f24c20b7
Source identifiers:
112988
Local pid:
pubs:112988

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