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Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium.

Abstract:

We investigated the efficiency of activated polyamidoamine dendrimers, a new class of nonviral vectors, to transfect rabbit and human corneas in ex vivo culture. In addition to assessing the expression of a marker gene we have demonstrated that this approach can be used to induce the production of TNF receptor fusion protein (TNFR-Ig), a protein with therapeutic potential. Whole thickness rabbit or human corneas were transfected ex vivo with complexes consisting of dendrimers and plasmids con...

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Publication status:
Published

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Publisher copy:
10.1038/sj.gt.3300886

Authors


Rayner, SA More by this author
Isaacs, JD More by this author
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Journal:
Gene therapy
Volume:
6
Issue:
5
Pages:
939-943
Publication date:
1999-05-05
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
URN:
uuid:1552ba85-d117-4562-a256-7ce9cf151f02
Source identifiers:
18335
Local pid:
pubs:18335

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