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Treatment with an AMPA antagonist 12 hours following severe normothermic forebrain ischemia prevents CA1 neuronal injury.

Abstract:

The neuroprotective effects of 2,3-dihydroxy-6-nitro-7- sulfamoylbenzo(f)quinoxaline (NBQX), GYKI 52466, and MK-801 were tested following severe forebrain ischemia. Wistar rats were subjected to 10 min of normothermic ischemia and reperfused for 7 days. Necrotic hippocampal CA1 neurons were counted and expressed as a percentage (mean +/- SD). In Experiment 1, saline-treated rats sustained 81 +/- 20% damage to dorsal CA1. Rats given NBQX 30 mg/kg i.p. x3 lost 21 +/- 27% (p < 0.01). Neither ...

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Publication status:
Published

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Publisher copy:
10.1038/jcbfm.1993.116

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Journal:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Volume:
13
Issue:
6
Pages:
933-939
Publication date:
1993-11-05
DOI:
EISSN:
1559-7016
ISSN:
0271-678X
URN:
uuid:154ca118-91d6-49dd-91d1-3ae8f07ce012
Source identifiers:
80182
Local pid:
pubs:80182

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