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Enhanced osteoblastogenesis in three-dimensional collagen gels.

Abstract:

Growth and differentiation of osteoblasts are often studied in cell cultures. In vivo, however, osteoblasts are embedded within a complex three-dimensional (3D) microenvironment, which bears little relation to standard culture flasks. Our study characterizes osteoblast-like cells cultured in 3D collagen gels and compares them with cells in two-dimensional (2D) cultures. Primary rat osteoblasts and MC3T3-E1 cells were seeded within type I collagen gels, and differentiation was determined by mi...

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Publisher copy:
10.1038/bonekey.2014.55

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Journal:
BoneKEy reports
Volume:
3
Pages:
560
Publication date:
2014-01-01
DOI:
EISSN:
2047-6396
URN:
uuid:1549c125-a4da-4e4c-9a1e-e8eb2eb0c234
Source identifiers:
481512
Local pid:
pubs:481512
Language:
English

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