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Structure of a cephalosporin synthase.

Abstract:

Penicillins and cephalosporins are among the most widely used therapeutic agents. These antibiotics are produced from fermentation-derived materials as their chemical synthesis is not commercially viable. Unconventional steps in their biosynthesis are catalysed by Fe(II)-dependent oxidases/oxygenases; isopenicillin N synthase (IPNS) creates in one step the bicyclic nucleus of penicillins, and deacetoxycephalosporin C synthase (DAOCS) catalyses the expansion of the penicillin nucleus into the ...

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Publication status:
Published

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Publisher copy:
10.1038/29575

Authors


Valegård, K More by this author
van Scheltinga, AC More by this author
Ramaswamy, S More by this author
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Journal:
Nature
Volume:
394
Issue:
6695
Pages:
805-809
Publication date:
1998-08-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:1546d280-8e29-4ca5-a058-520f16bf2873
Source identifiers:
36656
Local pid:
pubs:36656

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