- Abstract:
-
Penicillins and cephalosporins are among the most widely used therapeutic agents. These antibiotics are produced from fermentation-derived materials as their chemical synthesis is not commercially viable. Unconventional steps in their biosynthesis are catalysed by Fe(II)-dependent oxidases/oxygenases; isopenicillin N synthase (IPNS) creates in one step the bicyclic nucleus of penicillins, and deacetoxycephalosporin C synthase (DAOCS) catalyses the expansion of the penicillin nucleus into the ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/29575
-
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- Journal:
- Nature
- Volume:
- 394
- Issue:
- 6695
- Pages:
- 805-809
- Publication date:
- 1998-08-05
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- URN:
-
uuid:1546d280-8e29-4ca5-a058-520f16bf2873
- Source identifiers:
-
36656
- Local pid:
- pubs:36656
- Copyright date:
- 1998
Journal article
Structure of a cephalosporin synthase.
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