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Intravenous endothelin-1 and ventilatory sensitivity to hypoxia in humans.

Abstract:

The effects of intravenous endothelin-1 (ET-1) on the ventilatory response to hypoxia were studied in healthy humans. Nine volunteers were each exposed twice to 4 hr eucapnic hypoxia. They received a continuous infusion of ET-1 during the ET-1 protocol and an infusion of saline during the control protocol. Plasma ET-1 levels and an index of ventilation were measured regularly. Hypoxia caused a rise in plasma ET-1 in the control protocol. Hypoxia also caused the index of ventilation to increas...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Advances in experimental medicine and biology
Volume:
605
Pages:
57-62
Publication date:
2008-01-01
DOI:
ISSN:
0065-2598
URN:
uuid:154560ca-4f1f-4c4d-880e-2a23d6900c41
Source identifiers:
114387
Local pid:
pubs:114387

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