Intravenous endothelin-1 and ventilatory sensitivity to hypoxia in humans.

Journal article

The effects of intravenous endothelin-1 (ET-1) on the ventilatory response to hypoxia were studied in healthy humans. Nine volunteers were each exposed twice to 4 hr eucapnic hypoxia. They received a continuous infusion of ET-1 during the ET-1 protocol and an infusion of saline during the control protocol. Plasma ET-1 levels and an index of ventilation were measured regularly. Hypoxia caused a rise in plasma ET-1 in the control protocol. Hypoxia also caused the index of ventilation to increase in both protocols, and this increase was greater in the ET-1 protocol than in the control protocol. These results are consistent with the hypothesis that ET-1 plays a role in controlling the ventilatory response to hypoxia in man.

Authors: Talbot, N; Balanos, G; Robbins, P; Dorrington, K

• Publication status: Published
• Journal: Advances in experimental medicine and biology
• Volume: 605
• Pages: 57-62
• Publication date: 2008-01-01
• DOI: 10.1007/978-0-387-73693-8_10
• ISSN: 0065-2598
• Language: English
• Keywords: Male; Injections, Intravenous; Respiratory Physiological Phenomena; Endothelin-1; Female; Humans; Adult; Tidal Volume; Anoxia