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Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1

Abstract:

Virus diversity and escape from immune responses are the biggest challenges to the development of an effective vaccine against HIV-1. We hypothesized that T-cell vaccines targeting the most conserved regions of the HIV-1 proteome, which are common to most variants and bear fitness costs when mutated, will generate effectors that efficiently recognize and kill virus-infected cells early enough after transmission to potentially impact on HIV-1 replication and will do so more efficiently than wh...

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Publisher copy:
10.1038/mt.2013.248

Authors


Borthwick, N More by this author
Ondondo, B More by this author
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Journal:
Molecular Therapy
Volume:
22
Issue:
2
Pages:
464-475
Publication date:
2014-02-05
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
URN:
uuid:1539209f-f9fc-4b02-bf76-5e1eeadef188
Source identifiers:
458048
Local pid:
pubs:458048
Language:
English

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